4 national major scientific instruments and equipment development projects passed inspection

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[ Instrument Network Instrument R & D ] Recently, “Development and Application of Cesium Atomic Fountain Reference Clock”, “Development and Application of Cross-Scale Micro / Nanometers”, “Microfilm Pump-Driven Nucleic Acid Micro-Total Analyzer”, organized and implemented by the State Administration of Market Supervision "" Proton Transfer Reaction Mass Spectrometer Instrument Development and Application Demonstration "4 national major scientific instrument and equipment development projects passed the acceptance check.
The project "Development and Application of the Reference Clock of Cesium Atomic Fountain" was led by Academician Li Tianchu, Chinese Academy of Metrology. The project conquered key technologies such as cold atom preparation, cooling and detection, ultra-stable microwave generation, and optical fiber high-fidelity transmission time and frequency, and successfully developed a cesium atomic fountain reference clock (NIM6), a fiber-optic frequency transmission instrument, a rubidium fountain standard clock, and a radon fountain Clock engineering prototypes and other instruments. Among them, the frequency uncertainty of NIM6 is better than 5.8E-16, which is equivalent to 54 seconds in 1 second. The optical fiber frequency transmission instrument can transmit with high stability and high reliability on a fiber link of 1-100 km. Frequency signal; the frequency accuracy of the standard clock of the é“· fountain standard clock can reach 1.9E-15 after calibration. The project results provide measurement support for the generation, maintenance, improvement, and comparison of the standard time scales of the Beijing Satellite Navigation Center's time-frequency system. It is of great significance for building an independent, accurate, and reliable time-frequency system in China.
Cesium atomic fountain reference clock
"Development and application of cross-scale micro-nanometers" project was led by Shanghai Metrology and Testing Technology Research Institute. The project overcomes macro-micro linkage multi-axis drive and multi-probe integration, atomic deposition grating nanometer value traceability, dual-angle tilt Key technologies such as field scanning, developed 6 different types of cross-scale micro-nanometers with a measurement range of 150mm × 150mm × 80mm, a standard nanometer grating pitch of 212.8 ± 0.1nm, a grating height greater than 60nm, and optical interference measurement vertical The scanning range is 150 μm, the scanning speed is 30 μm / s, and the scanning probe micro-measurement can achieve nanometer resolution. Project achievements provide testing support for micro-nano standards, precision optical instruments, semiconductors, environmental monitoring and other fields, and have been promoted and applied in aerospace, microelectronics, environmental monitoring and other fields, laying a foundation for improving China's micro-nano field measurement capabilities. .
High-precision cross-scale micro-nanometer
The project of “micro-membrane pump-driven nucleic acid micro-total analyzer” is jointly undertaken by China Academy of Inspection and Quarantine, Beijing Bohui Innovation Biotechnology Co., Ltd., etc. The project overcomes the core technology of nucleic acid micro-total analysis instrument, microfluidic drive control platform and high-tech The core and key technologies of flux detection and fluorescence detection unit integration have developed a multifunctional nucleic acid micro-total analyzer and a portable nucleic acid micro-total analyzer. Aiming at the different application needs in the fields of environmental monitoring, biometrics, inspection and quarantine, disease diagnosis and research, etc., multiple bottlenecks such as simultaneous high-throughput, high-sensitivity, fast, accurate and quantitative detection on the spot are solved, and the detection sensitivity is comparable to conventional PCR sensitivity is an order of magnitude higher, and the detection time is 1/5 of that of conventional PCR methods. Through the implementation of this project, the first domestic automated production line for microfluidic chips, a multifunctional nucleic acid micro-analyzer, and CFDA registration supporting HPV chip reagents were obtained and marketed. The sales volume was 550 and HPV was launched in more than 450 hospitals. Testing has sold more than 1.8 million servings of reagents.
Multifunctional nucleic acid micro-total analyzer
The "Proton Transfer Reaction Mass Spectrometer Instrument Development and Application Demonstration" project is jointly undertaken by Beijing Metrology and Testing Scientific Research Institute and Beijing Kaier Technology Development Co., Ltd., etc. The project is aimed at rapid tracking of atmospheric smog pollution sources, and toxic and harmful gases in manned space capsules. The urgent need for online, real-time, ultra-trace volatile organic compound detection equipment in monitoring, chemical poison terrorist attacks in public places, etc., focuses on overcoming high-precision proton transfer ion sources, dual-field acceleration of time-of-flight mass spectrometry and gridless reflection, quadrupole Key technologies such as the acquisition and extraction of wide dynamic range signals from rod mass spectrometers, fast on-line digital filtering, and the development of high-precision mass spectrometry standard gases have successfully developed proton transfer reaction time-of-flight mass spectrometers (PTR-TOFMS) and quadrupole proton transfer mass spectrometers PTR-QMS), has realized the real-time, fast, high-sensitivity detection of multi-component volatile organic compounds, and the key technical indicators such as mass resolution and detection limit have reached the level of similar international instruments. The project research results have been applied in areas such as atmospheric haze monitoring, enclosed cabin environmental monitoring, import and export orange juice origin tracing, and rapid screening for lung cancer patients, etc., and have extensive application prospects.
Proton transfer reaction time-of-flight mass spectrometer

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